AustralieFrV1, Main, Exploration, bibRecord, 008312

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Identifieur interne : 008312 ( Main/Exploration ); précédent : 008311; suivant : 008313

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Auteurs : Jeffrey C. Barrett [Royaume-Uni] ; David G. Clayton [Royaume-Uni] ; Patrick Concannon [États-Unis] ; Beena Akolkar [États-Unis] ; Jason D. Cooper [Royaume-Uni] ; Henry A. Erlich [États-Unis] ; Cécile Julier [France] ; Grant Morahan [Australie] ; J Rn Nerup [Danemark] ; Concepcion Nierras [États-Unis] ; Vincent Plagnol [Royaume-Uni] ; Flemming Pociot [Danemark] ; Helen Schuilenburg [Royaume-Uni] ; Deborah J. Smyth [Royaume-Uni] ; Helen Stevens [Royaume-Uni] ; John A. Todd [Royaume-Uni] ; Neil M. Walker [Royaume-Uni] ; Stephen S. Rich [États-Unis]

Source :

Nature genetics [ 1061-4036 ] ; 2009.

RBID : Pascal:09-0271182

Descripteurs français

Pascal (Inist)
- Association, Métaanalyse, Locus, Risque, Diabète de type 1, Echelle du génome.
Wicri :
- topic : Association.

English descriptors

KwdEn :
- Association, Locus, Metaanalysis, Risk, Type 1 diabetes.

Abstract

Type 1 diabetes (T1 D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10^-6). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 ×10^-8) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

Affiliations:

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Le document en format XML

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<author><name sortKey="Todd, John A" sort="Todd, John A" uniqKey="Todd J" first="John A." last="Todd">John A. Todd</name>
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<author><name sortKey="Walker, Neil M" sort="Walker, Neil M" uniqKey="Walker N" first="Neil M." last="Walker">Neil M. Walker</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital</s1>
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<region type="country">Angleterre</region>
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</placeName>
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<author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Center for Public Health Genomics, University of Virginia</s1>
<s2>Charlottesville, Virginia</s2>
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<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
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<affiliation wicri:level="2"><inist:fA14 i1="10"><s1>Department of Public Health Sciences, Division of Biostatistics and Epidemiology, University of Virginia</s1>
<s2>Charlottesville, Virginia</s2>
<s3>USA</s3>
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<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
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<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2009">2009</date>
</imprint>
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<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Locus</term>
<term>Metaanalysis</term>
<term>Risk</term>
<term>Type 1 diabetes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Association</term>
<term>Métaanalyse</term>
<term>Locus</term>
<term>Risque</term>
<term>Diabète de type 1</term>
<term>Echelle du génome</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Type 1 diabetes (T1 D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10<sup>-6</sup>
). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 ×10<sup>-8</sup>
) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Danemark</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Californie</li>
<li>Maryland</li>
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<li>Île-de-France</li>
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<settlement><li>Cambridge</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName><li>Université de Cambridge</li>
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<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Barrett, Jeffrey C" sort="Barrett, Jeffrey C" uniqKey="Barrett J" first="Jeffrey C." last="Barrett">Jeffrey C. Barrett</name>
</region>
<name sortKey="Clayton, David G" sort="Clayton, David G" uniqKey="Clayton D" first="David G." last="Clayton">David G. Clayton</name>
<name sortKey="Cooper, Jason D" sort="Cooper, Jason D" uniqKey="Cooper J" first="Jason D." last="Cooper">Jason D. Cooper</name>
<name sortKey="Plagnol, Vincent" sort="Plagnol, Vincent" uniqKey="Plagnol V" first="Vincent" last="Plagnol">Vincent Plagnol</name>
<name sortKey="Schuilenburg, Helen" sort="Schuilenburg, Helen" uniqKey="Schuilenburg H" first="Helen" last="Schuilenburg">Helen Schuilenburg</name>
<name sortKey="Smyth, Deborah J" sort="Smyth, Deborah J" uniqKey="Smyth D" first="Deborah J." last="Smyth">Deborah J. Smyth</name>
<name sortKey="Stevens, Helen" sort="Stevens, Helen" uniqKey="Stevens H" first="Helen" last="Stevens">Helen Stevens</name>
<name sortKey="Todd, John A" sort="Todd, John A" uniqKey="Todd J" first="John A." last="Todd">John A. Todd</name>
<name sortKey="Walker, Neil M" sort="Walker, Neil M" uniqKey="Walker N" first="Neil M." last="Walker">Neil M. Walker</name>
</country>
<country name="États-Unis"><region name="Virginie"><name sortKey="Concannon, Patrick" sort="Concannon, Patrick" uniqKey="Concannon P" first="Patrick" last="Concannon">Patrick Concannon</name>
</region>
<name sortKey="Akolkar, Beena" sort="Akolkar, Beena" uniqKey="Akolkar B" first="Beena" last="Akolkar">Beena Akolkar</name>
<name sortKey="Concannon, Patrick" sort="Concannon, Patrick" uniqKey="Concannon P" first="Patrick" last="Concannon">Patrick Concannon</name>
<name sortKey="Erlich, Henry A" sort="Erlich, Henry A" uniqKey="Erlich H" first="Henry A." last="Erlich">Henry A. Erlich</name>
<name sortKey="Nierras, Concepcion" sort="Nierras, Concepcion" uniqKey="Nierras C" first="Concepcion" last="Nierras">Concepcion Nierras</name>
<name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name>
<name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S." last="Rich">Stephen S. Rich</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Julier, Cecile" sort="Julier, Cecile" uniqKey="Julier C" first="Cécile" last="Julier">Cécile Julier</name>
</region>
</country>
<country name="Australie"><noRegion><name sortKey="Morahan, Grant" sort="Morahan, Grant" uniqKey="Morahan G" first="Grant" last="Morahan">Grant Morahan</name>
</noRegion>
</country>
<country name="Danemark"><noRegion><name sortKey="Nerup, J Rn" sort="Nerup, J Rn" uniqKey="Nerup J" first="J Rn" last="Nerup">J Rn Nerup</name>
</noRegion>
<name sortKey="Pociot, Flemming" sort="Pociot, Flemming" uniqKey="Pociot F" first="Flemming" last="Pociot">Flemming Pociot</name>
</country>
</tree>
</affiliations>
</record>

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

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